Hyperglycemia, Type 2 Diabetes, and Depressive Symptoms: The British Whitehall II study
Identifieur interne : 008289 ( Main/Exploration ); précédent : 008288; suivant : 008290Hyperglycemia, Type 2 Diabetes, and Depressive Symptoms: The British Whitehall II study
Auteurs : Mika Kivimaki [Royaume-Uni, Finlande] ; Adam G. Tabak [Royaume-Uni, Hongrie] ; G. David Batty [Royaume-Uni, Australie] ; Archana Singh-Manoux [Royaume-Uni, France] ; Markus Jokela [Royaume-Uni] ; Tasnime N. Akbaraly [Royaume-Uni, France] ; Daniel R. Witte [Danemark] ; Eric J. Brunner [Royaume-Uni] ; Michael G. Marmot [Royaume-Uni] ; Debbie A. Lawlor [Royaume-Uni]Source :
- Diabetes care [ 0149-5992 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Royaume-Uni.
- topic : Prospective, Santé publique, Nutrition, Homme.
English descriptors
- KwdEn :
Abstract
OBJECTIVE - To examine the recent suggestion that impaired fasting glucose may protect against depression, whereas a diagnosis of diabetes might then result in depression. RESEARCH DESIGN AND METHODS - Cross-sectional analysis of 4,228 adults (mean age 60.7 years, 73.0% men) who underwent oral glucose tolerance testing and completed the Center for Epidemiologic Studies Depression scale (CES-D). RESULTS- After adjustment for demographic factors, health behaviors, and clinical measurements (BMI, waist circumference, lipid profile, and blood pressure), there was a U-shaped association between fasting glucose and depression (Pcurve = 0.001), with elevated CES-D at low and very high glucose levels. This finding was replicable with 2-h postload glucose (P = 0.11) and AlC(P= 0.007). CONCLUSIONS - The U-shaped association between blood glucose and CES-D, with the lowest depression risk seen among those in the normoglycemic range of AlC, did not support the hypothesized protective effect of hyperglycemia.
Url:
Affiliations:
- Australie, Danemark, Finlande, France, Hongrie, Royaume-Uni
- Angleterre, Grand Londres, Hongrie centrale, Languedoc-Roussillon, Nouvelle-Galles du Sud, Occitanie (région administrative), Écosse, Île-de-France
- Budapest, Glasgow, Londres, Montpellier, Paris, Sydney, Édimbourg
- University College de Londres, Université d'Édimbourg, Université de Glasgow
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Le document en format XML
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Tabak</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>First Department of Medicine, Semmelweis University Faculty of Medicine</s1><s2>Budapest</s2><s3>HUN</s3><sZ>2 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Medical Research Council Social and Public Health Sciences Unit, University of Glasgow</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</s1><s2>Edinburgh</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Renal and Metabolic Division, The George Institute for International Health</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>INSERM U687-IFR69, Assistance Publique-Hopitaux de Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Akbaraly, Tasnime N" sort="Akbaraly, Tasnime N" uniqKey="Akbaraly T" first="Tasnime N." last="Akbaraly">Tasnime N. Akbaraly</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM U 888, Montpellier</s1><s2>34093, Montpellier</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R." last="Witte">Daniel R. Witte</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Steno Diabetes Center</s1><s2>Gentofte</s2><s3>DNK</s3><sZ>7 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Steno Diabetes Center</wicri:noRegion></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J." last="Brunner">Eric J. Brunner</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G." last="Marmot">Michael G. Marmot</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Medical Research Council, Centre for Causal Analyses in Translational Epidemiology, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Diabetes care</title><title level="j" type="abbreviated">Diabetes care</title><idno type="ISSN">0149-5992</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort study</term><term>Depression</term><term>Endocrinology</term><term>Epidemiology</term><term>Great Britain</term><term>Human</term><term>Hyperglycemia</term><term>Metabolic diseases</term><term>Nutrition</term><term>Prospective</term><term>Public health</term><term>Type 2 diabetes</term><term>United Kingdom</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hyperglycémie</term><term>Royaume-Uni</term><term>Grande Bretagne</term><term>Diabète de type 2</term><term>Epidémiologie</term><term>Etude cohorte</term><term>Etat dépressif</term><term>Prospective</term><term>Santé publique</term><term>Endocrinologie</term><term>Maladie métabolique</term><term>Nutrition</term><term>Homme</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Royaume-Uni</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term><term>Santé publique</term><term>Nutrition</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE - To examine the recent suggestion that impaired fasting glucose may protect against depression, whereas a diagnosis of diabetes might then result in depression. RESEARCH DESIGN AND METHODS - Cross-sectional analysis of 4,228 adults (mean age 60.7 years, 73.0% men) who underwent oral glucose tolerance testing and completed the Center for Epidemiologic Studies Depression scale (CES-D). RESULTS- After adjustment for demographic factors, health behaviors, and clinical measurements (BMI, waist circumference, lipid profile, and blood pressure), there was a U-shaped association between fasting glucose and depression (P<sub>curve</sub> = 0.001), with elevated CES-D at low and very high glucose levels. This finding was replicable with 2-h postload glucose (P = 0.11) and AlC(P= 0.007). CONCLUSIONS - The U-shaped association between blood glucose and CES-D, with the lowest depression risk seen among those in the normoglycemic range of AlC, did not support the hypothesized protective effect of hyperglycemia.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Danemark</li><li>Finlande</li><li>France</li><li>Hongrie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hongrie centrale</li><li>Languedoc-Roussillon</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Budapest</li><li>Glasgow</li><li>Londres</li><li>Montpellier</li><li>Paris</li><li>Sydney</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université d'Édimbourg</li><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name></region><name sortKey="Akbaraly, Tasnime N" sort="Akbaraly, Tasnime N" uniqKey="Akbaraly T" first="Tasnime N." last="Akbaraly">Tasnime N. Akbaraly</name><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J." last="Brunner">Eric J. Brunner</name><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A." last="Lawlor">Debbie A. Lawlor</name><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G." last="Marmot">Michael G. Marmot</name><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><name sortKey="Tabak, Adam G" sort="Tabak, Adam G" uniqKey="Tabak A" first="Adam G." last="Tabak">Adam G. Tabak</name></country><country name="Finlande"><noRegion><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Tabak, Adam G" sort="Tabak, Adam G" uniqKey="Tabak A" first="Adam G." last="Tabak">Adam G. Tabak</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name></region><name sortKey="Akbaraly, Tasnime N" sort="Akbaraly, Tasnime N" uniqKey="Akbaraly T" first="Tasnime N." last="Akbaraly">Tasnime N. Akbaraly</name></country><country name="Danemark"><noRegion><name sortKey="Witte, Daniel R" sort="Witte, Daniel R" uniqKey="Witte D" first="Daniel R." last="Witte">Daniel R. Witte</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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